Centers work selected as Top 10 Best Papers Advancing the Science of Risk Assessment for 2012

Center’s work selected as “Top 10 Best Papers Advancing the Science of Risk Assessment” for 2012

A recently published work by the Center investigators has been selected by the Society of Toxicology’s Risk Assessment Specialty Section as one of the “Top 10 Best Papers Advancing the Science of Risk Assessment” for 2012. Lock E, et al. (Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci. 126(2):574–588, 2012) demonstrated the feasibility of an in vitro model system to assess inter-individual and population-wide variability of chemical-induced toxicity phenotypes. “As toxicity testing shifts from in vivo to in vitro to efficiently prioritize chemicals for their potential human health hazard, better understanding is needed of how inter-individual variability component of toxicity testing can be captured,” said Ivan Rusyn, the Principal Investigator of the Center and professor of Environmental Sciences and Engineering at UNC. The manuscript details the results of a study that used about 100 human lymphoblast cell lines and 240 chemicals at 12 concentrations to evaluate inter-individual differences in cytotoxicity and apoptosis. “This work demonstrates how the improved resolution of genetic and gene expression profiling can now be matched with high-quality in vitro screening data and potentially incorporated into next-generation of human health assessments,” adds Fred Wright, Center co-investigator and professor of Biostatistics at UNC. The evaluation of the toxicity pathways and the effects of genetic diversity are now feasible through the use of a genetically-defined and –diverse human in vitro cell system. This work was a collaborative effort with the NIH’s Division of the National Toxicology Program (National Institute of Environmental Health Sciences) and the Chemical Genomics Center (National Center for Advancing Translational Sciences).


Feburary 28, 2013