HAP-SAMPLE Provides Web Tool for Simulating SNP Genotypes


A website developed by researchers at the Renaissance Computing Institute (RENCI) and the University of North Carolina at Chapel Hill will give biologists access to a new tool to help them create large, simulated sets of human genetic data that will enable more accurate studies on the relationship between genetic mutations and disease. The web-based tool, called HAP-SAMPLE, has already been used by several research groups in the U.S. and Europe during pre-release testing. It was developed through the Carolina Center for Exploratory Genetic Analysis, a collaborative project led by researchers from CCGS and RENCI. CCGS researchers involved in the development of HAP-SAMPLE include Fred Wright, Pat Sullivan, Kirk Wilhelmsen, Fei Zou, and Fernando Pardo-Manuel de Villena. Fred Wright is also the lead author of a recent publication describing this simulation tool:

Simulating association studies: a data-based resampling method for candidate regions or whole genome scans. Wright FA, Huang H, Guan X, Gamiel K, Jeffries C, Barry WT, Pardo-Manuel F, Sullivan PF, Wilhelmsen KC, Zou F. Bioinformatics. 2007 Sep 4; [Epub ahead of print]

HAP-SAMPLE website
RENCI press release
International News Service release


September 20, 2007